Validation of a novel cortical
biomarker signature for pain
Because of the difficulty in treating chronic pain, development of brain signal predictive biomarkers is of
growing interest. Here we propose to develop a predictive biomarker signature of pain severity and duration
using two commonly available techniques – electroencephalogram (EEG) and transcranial magnetic
stimulation (TMS) – and perform initial clinical validation in first onset temporomandibular disorder (TMD). The
biomarker could have utility in identifying patients at high risk of transitioning from acute to chronic pain, and
has additional potential for clinical application in the treatment and prevention of chronic pain.